The Chelsea Lately host and comedian expressed her displeasure with the new trend of women undergoing anal bleaching in an interview with Glamour.
"I'm not sure you'll print this. First, it was laser hair removal. You put yourself through that torture, and then it's 'Sorry, laser hair removal's out of style!' And you're like, 'What?' So I'm not going to be tricked into this other thing," Handler explained.
"I might put a Crest Whitestrip up there, but I will not go and bleach it. My mouth has gotten me in trouble my entire life. I just happen to be making a career out of it."
Handler currently has a sitcom in the works entitled Are You There, Vodka? It's Me, Chelsea based on her memoir of the same name.
Earlier this year, Handler was at the centre of a controversy with a Serbian Facebook group who called for a boycott of Chelsea Lately following comments she made about the country on the programme.