The trial, which has lasted close to six weeks, went to the jury on Thursday following final statements from Deputy District Attorney David Walgren and Murray's defence attorney Ed Chernoff.
"For Michael Jackson's children, this case goes on forever because they do not have a father. They do not have a father because of the actions of Conrad Murray," Walgren told the jury.
Citing Murray's delay in alerting 911 to Jackson's serious condition during his final hours, he added: "What was so pressing that he couldn't just care for Michael Jackson? That is consciousness of guilt. That is Conrad Murray knowing full well what caused Michael Jackson's death."
However, Chernoff rejected the prosecution's accusations, telling the court: "If it was anybody else, would this doctor be here today?
"They want you to convict Dr Murray for the actions of Michael Jackson."
The twelve-person jury, consisting of seven men and five women, will begin its deliberations on Friday (November 4).
Earlier this week, Murray announced that he had decided not to testify in the case.
It was reported on Monday that defence witness Dr Paul White is facing a possible contempt of court charge and a $1,000 (£622) fine.
White will face a contempt hearing on November 16 which will allow him to explain his actions before the court.