The comic revealed that her Rosie Show writers were shocked to hear that she didn't want to tell any Kardashian jokes because she is not interested in the reality stars.
O'Donnell told The Billy Bush Show: "I've never seen any of the Karadshian shows, I don't really know the family or the story, all I know is Bruce Jenner looks weird, right?... When that all that [happened], the writers were like, 'We've got a bunch of Kim Kardashian jokes'. And I looked at them and I went… 'I don't really care'."
The Rosie Show host went on to compare the Kardashians to the Gabor sisters, whose romantic exploits occasionally outshone their career achievements.
O'Donnell explained: "I don't really know them. I saw recently, when Kim was doing her, 'Sorry, I got divorced tour', I saw the other sister who I thought was the older sister, but apparently is the younger sister [Khloe], who said on the air, 'I know I got married in nine days'. I'm thinking, 'I missed that whole thing'.
"There's so much to catch up with them. I feel like they're the Gabor sisters of this era. It's like Zsa Zsa and Eva at the height of their fame. I think that in some ways, they're the new Gabor sisters, but I don't have time."
Kim filed for divorce from husband Kris Humphries last week after just 72 days of marriage and has been in hiding since returning early from an Australian promotional tour.
The reality star will reportedly begin filming director Tyler Perry's movie The Marriage Counsellor very soon.
> Kris Jenner on SNL Kim Kardashian divorce skit: 'You have to laugh'
> Kris Jenner: 'Kim Kardashian needs to cry'
Watch Saturday Night Live spoof Kim Kardashian's divorce below (US only):