Murray was found guilty of the involuntary manslaughter of Jackson this week and is currently remanded in custody until his sentencing on November 29.
He faces a possible four years in jail for allegedly administering a lethal dose of the powerful anesthetic propofol to Jackson prior to the singer's death.
Murray told Today's Savannah Guthrie in an interview taped before the verdict that he acted entirely appropriately when Jackson showed signs of ill health on June 25, 2009.
"I don't feel guilty because I did not do anything wrong. I am very, very sorry for the loss of Michael. Michael was a personal friend. It's heartfelt [and] it's been painful."
Murray admitted that he left Michael's bedside for a short time in the moments before Jackson's death, but maintained that he has no regrets over the decision to step away from his patient.
"I regret [only] that Michael has passed," the physician said.
Murray denied that he administered a lethal dose of propofol to Jackson in the moments before his death, adding that he is still not sure how the drug got into the popstar's system.
"Something happened when I was not in that room. As to how it happened and the mechanisms, I don't know that," he commented.
"I think experts can say whatever they want without a full deck, but who knows by the time I discovered him [if he would have] not died?" he asked.
In a previous excerpt from his Today interview, Murray insisted that he loved Michael Jackson as much as anyone and never wanted any harm to come to his patient.
Murray will further discuss his feelings on Jackson's death in the documentary Michael Jackson and The Doctor, airing tonight (Friday) at 10pm ET on MSNBC.
Michael's brother Jermaine Jackson has condemned MSNBC's decision to air Murray's documentary and called the doctor both a "coward" and a "liar".
> Conrad Murray: 'I felt entrapped, betrayed by Michael Jackson'
> Michael Jackson brother Jermaine: 'Conrad Murray needs harsh sentence'