The Snow White and the Huntsman actress revealed that she is not used to being single, but is finally without a partner for the first time in decades.
"I've never been single. This is the first time in my life. From the time I was 19, I've been in relationships, literally gone from one to the other within a month," Theron explained in a new interview with Vogue.
"Being single's been good for me. I'm a creature who's really found her comfort zone in relationships."
Theron also spoke out on her January 2010 split from long-time boyfriend Stuart Townsend after nine years together.
"It was sinking, and I had to give it a fight. I really wanted to try and make it work. That was the priority. I wouldn't do it any different way," she said.
Theron has insisted that marriage is not important to her and is not necessary for a fulfilling relationship.
Watch the trailer for Snow White and the Huntsman below: