The E! news anchor, who revealed her breast cancer diagnosis in October, announced on Monday that she will undergo the operation to reduce the risk of further illness in the future.
"Overall, she's in unbelievably great spirits. She's been working a lot. It keeps her motivated," a source close to Giuliana told US Weekly.
The source went on to say that Giuliana's husband Bill has been incredibly supportive, adding: "They want to go into 2012 with a clean slate and put this all behind them."
Bill tweeted his appreciation for the support from fans, writing: "Thank you for the outpouring of prayers for Giuliana!"
Giuliana later followed up her husband's tweet, posting: "Yes... Thank u all!"
> Giuliana Rancic: 'Cancer support helped me recover quickly'