The former Saturday Night Live star explained that he learned early in his career to never 'tailor' his routine to any audience.
"I don't know any comedian who tailors his act to his audience. Maybe people say they do, but I can't even imagine them," he told The Huffington Post.
"I think if you try to tailor your act to anybody, you end up with an act that doesn't work anyway."
The Emmy nominee continued: "You can't make everybody laugh. You gotta just do what you think is funny. Just be obstreperous to everybody.
"That's the beauty of being a comedian - it's the one job you're allowed to do that. We're lucky. We're really lucky."
Last weekend, Quinn sparred with current Saturday Night Live headwriter Seth Meyers over a parody of the Penn State sex scandal.
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Watch Colin Quinn on The Late Show with David Letterman below: