"I am a jeans lover. I literally live in them," she shared to People. "So I wanted them to be as comfortable as they make me feel."
20% of the sales for every pair of 'Kaley' skinny jeans purchased will be donated to the Friends of Animals Foundation, a non-profit no-kill rescue and shelter for animals.
Cuoco said: "It wasn't a tough choice. We have to give a voice to the creatures that don't have one."
The Big Bang Theory star recently announced her engagement to her boyfriend Josh Resnik.
Cuoco will host the People's Choice Awards 2012, airing January 11, 2012 on CBS.
Watch a clip of Kaley Cuoco's appearance on The Ellen DeGeneres below: