The actress will appear nude in an upcoming Playboy spread, which is to be released early following a leak of some of the photos online.
The rapper - real name Curtis Jackson - explained that he has always "wondered" what Lohan looked like naked, and is looking forward to seeing the new photos.
"I always wondered what Lindsay's c**ch looked like," he told Hollyscoop. "Ever thought about it? I'll check it out and see what happens."
He added that he was surprised to hear Playboy paid Lohan $1 million (£625,000) for the shoot.
"$1 million to pose nude is the same thing strippers do almost every day for way less," he noted.
"If they give you $1 million, does that change the status of what you've done? If I pay $100 to see a c**ch, is it the same thing as paying $1 million when you're a movie star or celebrity? The same transaction? Or is it socially different? Does it register different because of how much?"
Lindsay Lohan was at one time rumoured to be recording a duet with 50 Cent.
She was recently linked with an appearance on Channel 5's next series of Celebrity Big Brother in the UK.
50 Cent announced details of a new fitness and diet guide last week.