The 50/50 star will host the annual awards show, which is set to be held on February 25, 2012.
"We're incredibly excited to have Seth as the host for the 2012 Film Independent Spirit Awards and join us in celebrating this year's exquisite films and talented filmmaking artists," said Film Independent senior director Sean McManus.
"Seth's charm, intelligence and quick wit are sure to light up the room and will make for a truly entertaining afternoon," he continued.
Meanwhile, Jennifer Caserta, executive vice president and general manager of IFC, described the actor as one of the funniest people alive, adding that she looks forward to seeing him take the stage.
"Seth is one of the smartest and funniest actors today and we look forward to him making this one of the most entertaining Spirit Awards yet," she said. "IFC is a growing brand for original comedy programming, and our viewers are in for a good time with Seth hosting."
Rogen recently slammed the 2011 Academy Awards for failing to take care of hosts James Franco and Anne Hathaway, claiming that the show did not provide material suitable for the actors.
In October, Rogen married his long-time girlfriend Lauren Miller in Sonoma.
Last year's ceremony was overseen by Community star Joel McHale.