The 25-year-old 'Video Games' singer has signed to the company's talent wing, which also includes the likes of Alexa Chung, Elle reports.
Other musicians signed to the agency include Ellie Goulding, Jessie J and Alice Dellal.
President of Polydor Records UK Ferdy Unger-Hamilton this week denied suggestions that Del Rey is a manufactured artist, insisting: "Lana knows what she wants like few artists I've ever met."
Del Rey last month revealed that she was inspired by Kurt Cobain and Nirvana when growing up, adding that "even at a young age, [she] really related to his sadness".
> Digital Spy's music ones to watch 2012
Watch Lana Del Rey's new 'Off to the Races' music video below: