The 'Marry the Night' singer and her mother Cynthia Germanotta have teamed up in the hopes of empowering and encouraging youth to develop self-confidence and stop bullying.
Cynthia said in a statement: "My daughter's foundation was born out of her passion to create a better world where people are kinder and nicer to one another and are accepted for who they are, regardless of how different they may be.
"She has experienced many of the struggles that our youth encounter today, and identifies with the lasting effects they can have without proper support. Together, we look forward to creating a new movement that will engage and empower youth and accept them as valuable members of our society."
The Born This Way Foundation will launch on February 29 at a gala held at Harvard University's Sanders Theater, where GaGa will be joined by the organisation's partners, Harvard's Berkman Centre for Internet and Society, the MacArthur Foundation and the California Endowment.
Last month, Lady GaGa travelled to the White House to discuss the importance of anti-bullying measures with President Barack Obama.
Lady GaGa is amongst the nominees for the 2012 GLAAD Media Awards, to be held during three different ceremonies in New York on March 24, Los Angeles on April 21, and San Francisco on June 2.
Watch Lady GaGa's video for "Marry the Night' below: