Broderick is to return to his iconic role as teen troublemaker Ferris Bueller in a new commercial for Honda, which is to air during Sunday's NFL Championship game between the New England Patriots and the New York Giants.
The advert has attracted considerable attention in the press and Ruck - who played Bueller's best friend Cameron in the film - was recently asked if he is looking forward to seeing it.
"Uh, no," Ruck replied to USA Today.
The actor expanded on his lack of enthusiasm for Bueller's return by saying: "Sometimes it does get a little bit old. Boy, that's the character that wouldn't die."
Ruck went on to stress that although he does get tired of being asked about Ferris Bueller's Day Off, he is glad that the film is reaching new audiences.
"I'm happy people still enjoy the movie. It's a nice escapist movie and it reminds a lot of people of their youth," he said. "It's always nice to be part of something that keeps going."
Ferris Bueller's Day Off has become an enduring classic since its release in 1986, having spawned a short-lived television spinoff and even academic studies.
Broderick's Ferris Bueller Super Bowl commercial is directed by The Hangover's Todd Phillips and features the film's signature song 'Oh Yeah'.
Madonna will be performing at the Super Bowl half-time show on Sunday, while Kelly Clarkson will open the game with the US National Anthem.
Watch an extended trailer for the Ferris Bueller Super Bowl advert below: