Hosted by Greg Burns at London's Cuckoo Club, there were also gongs for Shooting Stars duo Vic Reeves and Bob Mortimer, and 8 Out Of 10 Cats stars Jon Richardson and Jimmy Carr.
Brydon joined Frank Skinner and Harry Enfield in the 'Loaded Legend' hall of fame, while Fresh Meat was named 'Best TV Show'.
> Rob Brydon interview
Richardson took home the 'Funniest Man' accolade, while Andi Osho was crowned 'Funniest Woman' ahead of Isy Suttie and Sarah Millican. Chatty Man Alan Carr scooped the 'Best Stand-Up' title for his 2011 'Spexy Beast' tour.
Meanwhile, Not Going Out star Tim Vine triumphed in the 'Best Joke' category with his one line, "Conjunctivitus.com - that's a site for sore eyes." Vine beat Jimmy Carr to the title, but the 10 O'Clock Show star made up for his defeat by taking home the 'Funniest DVD' title.
Read the full winners list below:
Winner: Jon Richardson
Nominees: Al Murray, Jimmy Carr, Lee Evans, Leigh Francis
Winner: Alan Carr
Nominees: Jason Manford, Kevin Bridges, Micky Flanagan, Russell Kane
Winner: Andi Osho
Nominees: Isy Suttie, Katy Brand, Morgana Robinson, Sarah Millican
Funniest Double Act
Winner: Vic & Bob
Nominees: Anna Crilly and Katy Wix, Dick and Dom, Mitchell and Webb, The Chuckle Brothers
Best Panel Show
Winner: Celebrity Juice
Nominees: 8 out of 10 Cats, Ask Rhod Gilbert, Shooting Stars, Would I Lie to You
Funniest TV Show
Winner: Fresh Meat
Nominees: Chatty Man, Facejacker, Outnumbered, Phone Shop
Winner: The Inbetweeners
Nominees: Bridesmaids, Johnny English, Paul, The Hangover Part II
Winner: Gordon Smart
Nominees: Caitlin Moran, Grace Dent, Frankie Boyle
Funniest TV Personality
Winner: Lee Nelson
Nominees: Angelos Epithemiou, David Hasselhoff, Ian Beale, Jedward
Winner: Dom Joly
Nominees: Jimmy Carr, Matt Lucas, Richard Bacon, Stephen Merchant
Winner: Jimmy Carr: Being Funny
Nominees: Angelos Epithemiou & Friends Live, Jason Manford Live 2011, John Bishop Live - Sunshine Tour, Tim Minchin and The Heritage Orchestra - Live at The Royal Albert Hall
Winner: Pappy's Flatshare Slamdown
Nominees: Dom Joly's Celebrity Comedy Podcasts, The Danny Baker Show, The Dave Gorman Podcast, The Ricky Gervais Podcast
Funniest Radio Show
Winner: Danny Wallace, Xfm
Nominees: Christian O'Connell, Absolute Radio, Dave Berry, Capital FM, Hawksbee and Jacobs, Talk Sport, Shaun Keaveny, 6 Music Breakfast Show
Best Internet Viral Show
Winner: Misery Bear
Nominees: Alan Partridge, Harry Hill, The Fast Show, Vic & Bob
Winner: Pat Monahan
Nominees: Doc Brown, Frisky & Mannish, Josh Widdicombe, Roisin Conaty
Winner: Tim Vine: "Conjunctivitus.com – that's a site for sore eyes."
Jimmy Carr. "I know a couple who get on like a house on fire. They both feel trapped and are slowly suffocating to death."
Matt Kirshen: "I was playing chess with my friend and he said, 'Let's make this interesting'. So we stopped playing chess."
Paul Daniels: "I said to a fella 'Is there a B&Q in Henley?' He said 'No, there's an H, an E, an N an L and a Y'."
Sarah Millican: "My mother told me, you don't have to put anything in your mouth you don't want to. Then she made me eat broccoli, which felt like double standards."