The actress was seen leaving a doctor's office with the image of what appeared to be a black and white baby scan, according to TMZ.
Barrymore recently got engaged to 34-year-old art consultant Will Kopelman, who was present with her when she exited the medical building in Beverly Hills.
The actress's representatives declined to comment over whether she is expecting a baby.
Barrymore recently revealed that she is likely to take on fewer acting roles in the future.
The Big Miracle star claimed that she wants to spend more time focusing on her relationship with her fiancé this year.
She said: "I've done all of this for 35 years. I think maybe it's okay to put the life first for a minute. I don't really know this feeling. It's new and exciting."
Watch Drew Barrymore in the trailer for Big Miracle below: