The 'Fight For This Love' singer and former X Factor judge will take a young budding business person out for afternoon tea at a luxurious London hotel.
The Prince of Wales told guests: "One of the people who's here this evening, to whom I owe an awful lot, I think, is Cheryl Cole, who has been kind enough to come this evening and apart from anything else, to offer herself as an auction prize, but only for tea."
Michael McIntyre, Lulu and Jools Holland were also at the Prince's Trust evening, an 'Invest in Futures' event organised to help raise funds for young unemployed people in the UK.
Girls Aloud star Cole said: "This afternoon tea is a fun way to raise money for a charity close to my heart. I am a huge fan of the work of the Prince's Trust.
"My Foundation is supporting the work of the Prince's Trust in the North East, helping young people from my part of the world to get their lives on track. It's a really difficult time for young people at the moment."
The 28-year-old set up her charity The Cheryl Cole Foundation with Prince Charles in February last year.