The legendary insult comedian is to be given the Johnny Carson Award by Jon Stewart at the upcoming New York City comedy gala.
Rickles was a close friend of Carson, appearing on The Tonight Show more than 100 times over the years.
David Letterman - who was also closely associated with Carson - received the prestigious honour at the 2011 Comedy Awards.
Robin Williams's life and career will also be saluted at The Comedy Awards when he is given the Stand-Up Icon trophy.
30 Rock, Modern Family and Saturday Night Live lead this year's television Comedy Award nominees, while Bridesmaids, Midnight in Paris and Crazy, Stupid, Love have all received multiple nods in the movies categories.
The second annual Comedy Awards will be taped at New York City's Hammerstein Ballroom on April 28, 2012.
The awards show will then air on Comedy Central on May 6 at 9/8c.
> The Comedy Awards 2012: Nominations in full
Watch a special look at last year's Comedy Awards below (US only):