The stand-up comic will honour online achievement on behalf of the International Academy of Digital Arts and Sciences in May.
Winners will be asked to keep their acceptance speeches to five words or less in keeping with the organisation's long-standing tradition.
The full list of nominees will be announced in the coming week, with the winners being confirmed on May 1. More than 10,000 entries have been received.
Past celebrity Webby winners have included Stephen Colbert, Michel Gondry, David Bowie, Tim & Eric and Lorne Michaels.
The 16th annual Webby Awards will be held at the Hammerstein Ballroom in New York City on May 21.
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