The Australian comedian, who is best known for his role as one of the hosts of The Project, said that he respects his wife Holly Ife for taking care of their two children Rafferty and Sadie while he goes out to work.
Hughes told The Age: "I swear to God, being at home with two kids is the hardest work as anything I've ever done.
"When you get home and you've got an 11-month-old who is walking early, who is trying to kill herself every five seconds by putting something in her mouth or walking off the edge of a balcony - that is hard as well."
Hughes added that he was not happy when Channel Ten decided to add an extra episode of The Project each week, making his schedule even more hectic.
He said: "I remember where I was when I got the call from my manager. I said: 'Really?' I was shocked. We all were. I won't deny it."
Hughes also said that stand-up comedy is still his "first love" and admitted that he doesn't want to stick to TV roles for so long that it makes him "fall out of the habit" of getting on stage.
He added that the "reward" of stand-up comedy is the job itself, "not the money".
The Project has been nominated for a Logie Award for 'Most Outstanding Light Entertainment', while Hughes's co-host Carrie Bickmore is up for the prestigious Gold Logie award.
> Channel Ten boss remains positive about 'The Project' ratings defeat
> Dave Hughes: 'I thought 'The Project' would ruin my career'