The Nurse Jackie star welcomed her son Anderson in 2005 and daughter Macy in 2008.
Falco has now explained why she went through the process in an appearance on Thursday's Anderson.
"At that time I was single and the idea to adopt came to me," she said. "I just knew at a certain point it was time to raise kids."
Falco admitted that she isn't sure whether her children realise that other kids aren't adopted yet but revealed that she has no concerns about the situation.
"I don't [worry] because I am really clear in my head what it's all about," she said. "The second you are handed a newborn, it is yours. It doesn't matter what body it came out of. I've never felt more strongly about anything in my life."
The fourth season of Nurse Jackie airs on Sundays on Showtime.
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Watch Edie Falco on Anderson below: