The 'Strong Enough' singer will receive the award at the charity's Unforgettable Evening gala later this week in LA.
Crow is being honoured for her charity work on behalf of cancer patients followingher own battle with breast cancer.
The singer has thrown several fundraising events for cancer sufferers and even opened her own Sheryl Crow Imaging Centre to help women prevent the disease.
The Women's Cancer Research Fund's Unforgettable Evening is held on Wednesday, April 18.
Rihanna will perform during the event and Steven Spielberg, Kate Capshaw, Rita Wilson and Tom Hanks are all expected to attend.
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Watch Sheryl Crow perform 'Strong Enough' with Stevie Nicks below: