The Source Code star will make his US stage debut in September in the comedy-drama If There Is I Haven't Found It Yet.
The play, penned by British scribe Nick Payne, centers on a young girl struggling with weight issues. Gyllenhaal will play the girl's uncle.
It is set to be directed by Michael Longhurst.
Gyllenhaal previously appeared on the stage in London.
Last month, the actor signed on to play dual roles in Denis Villeneuve's An Enemy.
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