The Falling Skies actor was taken into custody while taking part in a protest against Congress's proposed cutting of Medicaid, the US health programme for people and families with low incomes and resources in Washington DC on Monday.
Wyle was said to be one of more than 100 protesters arrested, most of whom belonged to disability rights organisation ADAPT, it was reported.
"As soon as everybody saw me being led away, they let up a big whooping cheer, which made me feel really good," he told The AP of the arrest. "I think [my kids] are really proud of the old man right now."
Wyle also discussed his reasons for participating in the event, explaining: "Those cuts would reduce the hours of home health care aides being able to come in and give basic services, which would force people to basically give up their right to live in integrated, portable, accessible housing and put them in an institution.
"[It's a] very short-sighted economic decision because it costs up to four times as much to have somebody in an institution than it does to have them require some hourly assistance every day."
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