The businessman boyfriend of Khloe's sister Kourtney Kardashian is expecting his first daughter later this year, and the couple are already parents to son Mason.
Khloe told Us Weekly: "I think he's nervous to have a little girl, because guys know what they were like when they were younger and they don't want their daughters to go through that.
"I'm sure he's going to be a little protective - and I'm sure Mason will be protective too."
Speaking at the opening of his Japanese eatery RYU in New York City, Disick agreed with the comments of his partner's sister.
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"I may be more protective [over her than Mason], but I don't want to be too protective. We'll see what happens," the 28-year-old said.
"They should write more manuals on how to raise kids, because it's tough!"
Meanwhile, Kardashian family matriarch Kris Jenner admitted her grandson is going to have some difficulty adjusting to having a sibling.
"He doesn't know what's going to hit him in a couple of months," she said. "But when there's so many of us, Mason and his new little sister are about to have a lot of babysitters!"
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