Palin railed against Obama's change of stance on gay marriage in a blog post earlier this week, suggesting that the president watched "one too many episodes of Glee" prior to his announcement.
Those comments prompted a fiery response from Jersey Shore star JWoww, who accused single mother Palin of hypocrisy.
JWoww tweeted: "Bristol should keep her uneducated ignorant mouth shut. If Ur living in the past u wouldn't have a kid w/out marriage #hypocrite. It's 2012!
'My best friend will get married one day and not just have civil union with his man. Stop hating people."
Palin has yet to respond to JWoww's tweets.
Obama's affirmation that he now supports gay marriage has been hailed as a progressive step by celebrities including Jane Lynch, Neil Patrick Harris and Eliza Dushku.
Lady GaGa also praised Obama on Twitter, writing: "Obama, congratulations on being the first sitting President to support marriage equality. Feels like the future, and not the past. #NoFear."