The 'Oh My Goodness' singer explained that he doesn't understand why some men struggle to be in the company of gay males.
"I'm a straight guy and I date women, but I get on really well with gay guys. I'm very comfortable with my sexuality," he told Australia's Star Observer.
"The weirdest thing for me is when straight guys get really freaked out by gay guys. It's almost like they're insecure in their own sexuality. For me, I can be in a room full of gay men and have fun."
He added: "The B-side from one of my first singles was called 'This One's For The Girls', so I changed it to 'This One's For The Boys' when I played at G-A-Y, and they loved it.
"The funniest thing is, I'm used to hearing high-pitched girl screaming after I play, and when I play to gay crowds it's more like [in a lower voice] 'YEAHHHH!'. It's like performing to the cast of the film 300."
Murs added that he has enjoyed his success as a popstar so far, but realises that it may not last forever.
"A lot of TV talent show people do come and go - one song or album, then they're gone," he said. "I've had three number ones and two successful albums at this point, which is so much more than I ever dreamed of.
"Even if the next single or the next album isn't as successful, I think I'll be OK with it, because I feel like I've already had a good run."
Murs will team up with Chiddy Bang for a reworked version of 'Heart Skips a Beat' as his debut US single.
Listen to Olly Murs's 'Heart Skips A Beat' featuring Chiddy Bang below: