The comedian told The Ellen DeGeneres Show that he still has great affection for Perry even after filing for divorce following just one year of marriage.
"I still love her as a human being, but, sometimes when you're in a relationship, I suppose it doesn't work out," Brand explained to Ellen DeGeneres. "That doesn't mean I regret it or anything. I was very happy to be married with her. She's such a beautiful human being and I just have only love and positivity for her."
He added of Perry: "That is still a person I still consider to be beautiful and I have nothing but positivity for her."
Brand's comments come just days after he stopped following Perry on Twitter.
The couple have both gone on to new romances since their separation, with Perry recently being linked to Florence + the Machine guitarist Robert Ackroyd.
Brand has also been rumoured to be dating David Hasselhoff's Playboy model ex-girlfriend Anouska de Georgiou.
His full interview on The Ellen DeGeneres Show airs Thursday (May 17).
Watch Russell Brand comment on Katy Perry below: