The Alice in Wonderland star has revealed in the past that he has Native American ancestry from his great-grandmother, who was a Cherokee Indian.
The 48-year-old actor is currently filming a remake of The Lone Ranger, in which he portrays Tonto, a fictional character belonging to the Comanche Nation.
According to The Hollywood Reporter, officials of the Comanche Nation decided to officially invite the actor to become a member of the tribe.
President of Americans for Indian Opportunity LaDonna Harris said: "Johnny is reprising the historic role of Tonto, and it seemed like a natural fit to officially welcome him into our Comanche family.
"I reached out, and Johnny was very receptive to the idea. He seemed proud to receive the invitation, and we were honoured that he so enthusiastically agreed."
Depp attended the ceremony at Harris's home in Albuquerque, New Mexico, where principal photography on The Lone Ranger is taking place.
The actor gave gifts to tribal leaders and took photographs with several members of the tribe during the ceremony.
This is not the first time Depp has met with Native American officials since filming began on The Lone Ranger. Both he and co-star Armie Hammer met with Navajo officials on the movie set several weeks ago.
Watch the trailer for Johnny Depp's current release Dark Shadows below: