The Ghost star slammed the press for having 'twisted' a Twitter message, which read "when your mind says give up, hope whispers one more try", to claim it referred to her ex-partner.
"You have to laugh at the media's need to twist and take tweets out of context so they can create fictitious stories to sell to the public," she wrote on the social networking site.
Later, the actress added: "Nice bit of wisdom passed on to me, 'the faster you find what's funny about something, the better it is!'"
Moore announced that she would divorce Kutcher in November 2011 after six years of marriage. The Two and a Half Men actor had been accused of cheating in the weeks leading up to their split.
Moore, who spent a brief stint in rehab in February, changed her Twitter handle from @mrskutcher to @justdemi earlier this month.
Watch the trailer for Demi Moore's LOL below: