The actress told Cosmopolitan that she does not mind feeling apart from her surroundings in the industry.
"I've always felt like an outsider and I still do when I go to fancy events. I still sit there and think, 'I don't belong here'," Deschanel said.
"I feel like a kid at the adults' table - like I'm an outsider who got let inside somehow. It's not a bad thing, it's just that I see everything differently.
"I take all the glitz and glamour of this business with a large grain of salt. I feel very removed from it. Not in a bad way - it's cool - I just don't feel a part of it."
Of being at awards shows, she continued: "I just think you go to something like the Golden Globes, and it's the most glamorous place you could ever be, but then you go home and you're still like, 'Urgh, this dress is too tight, I wanna take off these shoes and put on my pyjamas'.
"At the end of the night all the glamour goes away and you're just a human. All of that stuff is put on, to a degree. It's always comforting to know that, no matter what, at the end of the night I'm always home in my pyjamas."
Deschanel added: "I'm not shy. I have a strange sort of combination of awkwardness and confidence. I'm actually okay with awkward moments. But it's not because I think I'm so great.
"I'm confident in things other than, like, my 'swagger'. I'm confident in my sense of humour. I'm comfortable in my skin."
The full interview appears in the July issue of British Cosmopolitan, on sale June 7.