Payne tweeted a series of messages on Sunday (June 3) in defence of Danielle Peazer, who has been charged by some One Direction fans with only dating the singer because he is famous.
"Just as I start to like twitter again I see the nasty side of people who like to dislike somebody who makes me … Me," the 'What Makes You Beautiful' star wrote.
He added: ""#SometimesIHateTwitter when it becomes a place to abuse people who uve never met never did anything to you but you still choose to be cruel (sic).
"To all those people who are going to be d**ks and tweet her horrible stuff now just because i mentioned it … boring grow up."
Payne went on to thank One Direction fans who support his relationship with Peazer.
"To all those people who are nice thank you so much she often reads me nice things people say to her and it makes me smile love you guys."
Fellow One Direction star Louis Tomlinson recently defended his own girlfriend Eleanor Calder against online abuse from overzealous fans.
Watch One Direction's 'What Makes You Beautiful' music video below: