The An Officer and a Gentleman actress is joining The Anarchist to replace Laurie Metcalf, who has left the production due to scheduling reasons.
Tony Award winner Patti LuPone will co-star with Winger when The Anarchist makes its US debut.
The Anarchist is expected to premiere on November 13. A venue has not yet been determined.
The play is the latest from acclaimed writer David Mamet, whose previous hits include Speed-the-Plow and American Buffalo.
Winger has worked extensively on-stage before at the American Repertory Theater in Massachusetts, but has never before appeared on Broadway.
She most recently appeared on television in the HBO series In Treatment.
Watch Debra Winger in a scene from An Officer and a Gentlemen below: