The 25-year-old actress totalled her rented Porsche after colliding with the rear of an 18-wheeler truck.
Reports from the scene said that the Mean Girls star and her assistant were rushed to the emergency room after suffering minor injuries.
According to police, neither Lohan nor the driver of the truck were under the influence.
TMZ reports that the starlet has now left the UCLA hospital where she was briefly treated.
Lohan was on her way to the set of Liz & Dick when the crash occurred. The Lifetime television movie will star Lohan as Elizabeth Taylor during her tumultuous affair with actor Richard Burton.