The rapper reportedly said that he is interested in going into business with the Manchester United and England striker.
"I'm a big fan of Wayne Rooney, he's a brand," he told the Daily Star. "I want to become business partners with him. European soccer is a big business and there's money to be made with top players.
"I've met Wayne and he's a great guy. He's one of the top soccer players in the world and has a lot of years left in his career."
50 Cent - real name Curtis Jackson - said that he believes the pair could make a lot of money by teaming up.
"I am all about making money and I know my man Wayne is as well.
"The possibilities are endless. Restaurants in Europe, clothing stores, nightclubs. Making millions is cool, but making a billion is better, and Wayne knows it!"
He added: "When Euro 2012 is over I've invited Wayne and his family to stay at my place in Miami.
"Nobody will bother them or take photos of them over here. My people will make sure of that."
50 Cent is expected to release his fifth studio album FIVE (Murder By Numbers) on July 3.