The former boxing champion is partnering with director Spike Lee to produce the limited run at the Longcare Theater in New York, according to The AP.
Tyson speaks candidly about his career highs and lows in the show, including his troubled childhood, boxing career, drug addiction, and numerous legal troubles.
The 45-year-old recently performed a version of the show in a limited Las Vegas run at the MGM Grand.
"It is an honour to work with Spike Lee," Tyson said in his announcement on Monday (June 18). "I have always admired his work. Sharing the highlights and lowlights of my life with New York is especially important to me as I was born and raised in Brooklyn."
The ex-athlete recently appeared in The Hangover and The Hangover Part II. He is reportedly in line for another cameo in its follow-up, The Hangover III.