Jenner was asked about Kardashian's brief marriage on Monday (June 25)'s edition of Bethenny.
"What's a measly little 72 days?" she jokingly replied.
Jenner went on to give her blessing to her daughter's new romance with Kanye West and also revealed that she could see the pair tying the knot.
She explained: "With Kim, she falls in love really hard. She's a hopeless romantic. And I tell all of my children, 'Follow your heart'.
"Do what you feel and what you want. What you think is the right thing to do, but follow your heart. Be happy."
The reality star made those comments just as Kardashian insisted on Oprah's Next Chapter that she is "not thinking" about marrying West.
Jenner also used her appearance on Bethenny to deny that Kourtney Kardashian and Scott Disick are splitting.
Watch Kris Jenner discuss Kim Kardashian's love life on Bethenny below: