Katie Holmes filed for divorce from Cruise after five years of marriage on Friday (June 29).
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Reports have circulated that Holmes and Cruise differed on how to raise their children, with Cruise's belief in Scientology deemed to also be a major factor.
Murdoch commented earlier today (July 1) that he expects Scientology to be the main reason behind their break-up, and that he finds the religion "creepy and evil".
"Watch Katie Holmes and Scientology story develop. Something creepy, maybe even evil, about these people," he tweeted.
A few moments later, he added: "Since Scientology tweet hundreds of attacks. Expect they will increase and get worse and maybe threatening. Still stick to my story."
When asked by a follower if he was a Christian, he replied: "I try to be".
The couple are now expected to arrange a custody agreement for their daughter Suri in the coming weeks.
Russell Crowe recently denied that he will be playing Rupert Murdoch in an upcoming drama.
