The actress told Elle that she and a prospective partner would struggle to find somewhere to go.
"Is a guy going to come up to me and ask if he can take me out on a date?" Kunis said.
"Where can I go and have this date? I can't go anywhere! My house, his house... So what do you do?
"I'm trying to be like a normal girl and a single girl... but the concept of being single and in my position is just not workable. I couldn't even go on a date if I wanted to!"
Of her previous eight-year relationship with fellow actor Macaulay Culkin, she added: "Being settled so young really helped. You know, I wouldn't take back anything in my life, not one thing. I think it all shaped me to be who I am today.
"There are things that people know about, and there are things that the press doesn't know about, and everything that did occur 100% shaped who I am. My ex-boyfriend, my family, my friends, everybody."
Kunis said: "I have everything working against me at this point. I am a woman, I'm a child actress and I was on a television show for eight years.
"But I have worked really hard to prove them all wrong. It's the stubborn side of me. I still don't have a f**king clue what I'm doing.
"I'm not confident in my talent, whatever that might be, and I hope I never am. Working this hard is the thing that keeps me sane."
Read the full interview in the August issue of Elle on sale Wednesday, July 4. Also available in digital edition.