The Extra host told The Improper Bostonian that she is attracted to Clooney's talent and personality.
"Not to step on [Clooney's girlfriend] Stacy [Keibler]'s toes, because she's a good friend of mine, but I'll say George Clooney," she said.
"Because he's a great filmmaker and a great actor, and I really admire his skill. He's a true philanthropist. He's charming and courteous. And he's George Clooney."
Menounos was also asked to name her favourite celebrity couple during the interview and decided to choose Tom Hanks and Rita Wilson, saying: "They're what it should be.
"They're a great family. Amazing, normal, down-to-earth, genuine people. They love each other. I look up to them."
Menounos starred in the most recent season of Dancing with the Stars, but was voted out the week before the finale.