The Matlock star's friend and former UNC President Bill Friday told WITN that Griffith passed away at his North Carolina home on Tuesday morning local time (July 3).
Dare County, NC police spokesperson Doug Doughtie has now released a Griffith family statement to The AP confirming the actor's death.
"Mr Griffith passed away this morning at his home peacefully and has been laid to rest on his beloved Roanoke Island," the family statement read.
Police previously disclosed that an ambulance had been called to Griffith's home prior to news of his death first being reported.
The exact circumstances of Griffith's death are not yet known.
Griffith rose to fame in the 1950s starring as a charismatic and ultimately corrupt politician in Elia Kazan's film A Face in the Crowd.
He turned his talents to the emerging television industry following A Face in the Crowd by starring in the landmark sitcom The Andy Griffith Show, which ran from 1960 to 1968 on CBS and launched the careers of Ron Howard and Don Knotts.
Griffith returned to film work in the 1970s, including starring against type as a villain in the 1974 TV movie Savages.
He landed his second iconic television role in 1985 as a good natured criminal defence attorney in Matlock. Griffith played the role of Ben Matlock for 195 episodes over the course of nine seasons.
The actor was honoured with a star on the Hollywood Walk of Fame in 1960 and the Presidential Medal of Freedom in 2005.
He is survived by third wife Cindi Knight.
Watch the opening credits of The Andy Griffith Show below: