Referring to entering her 30s, the actress told the August edition of US Elle that she was about to enter "a new phase" - which some have speculated was an allusion to her impending single status.
"I definitely feel much more comfortable in my own skin," she said. "I feel sexier. I think in my 20s, it's like you're trying too hard to figure everything out.
"I'm starting to come into my own. It's like a new phase."
A source at the mid-May interview also told the New York Post that the 33-year-old repeatedly "deflected" questions about her then-husband, including one where she apparently reacts negatively to being dubbed 'Mrs Cruise'.
"He has been Tom Cruise for 30 years," Holmes allegedly said. "I know who I am and where I am and where I want to go, so I want to focus on that."
The issue of Elle featuring Holmes's interview goes on sale July 17.
Insiders have claimed that the star feels like she has "been set free" after being "miserable for a long time" with Cruise.