The Lovelace actress, who wore a Miu Miu dress at the 2012 Met Ball, will be the face for the brand's fall 2012 ad campaign, reports Fashionista.
Sevigny previously worked with Miu Miu in 1996, when she modelled for the brand for the first time.
Miu Miu is known for featuring Hollywood stars on their ad campaigns such as Kirsten Dunst, Lindsay Lohan, Hailee Steinfeld and Maggie Gyllenhaal.
Jane Eyre actress Mia Wasikowska was the latest celebrity to front the brand in its spring 2012 campaign.
Lovelace tells the story of former porn star Linda Lovelace. It stars Amanda Seyfried in the title role, supported by a cast including James Franco and Sharon Stone.
Watch Mia Wasikowska's advertising campaign for Miu Miu below: