Cole visited Clarence House last year to launch her charity The Cheryl Cole Foundation, which is run in conjunction with The Prince's Trust.
The Prince of Wales was said to be so impressed with Kristina Kyriacou, the long-term mentor to the 'Call My Name' singer who accompanied her on the visit, that he has hired her to help run his charity endeavours.
"It's a big move," a source told The Daily Telegraph. "His Royal Highness was frustrated that his charities, which do so much good work, were not getting the public attention that they deserve.
"He was very impressed with Miss Kyriacou and the work that she has done for the Prince's Trust with Cheryl Cole. He's convinced that she is just the person he needs to take his charities forward."
Kyriacou, who previously managed recent OBE recipient Gary Barlow, will continue to work with Cole as well as other showbiz clients.
A spokesman for Clarence House said: "Kristina Kyriacou has been given the title of assistant communications secretary, charities and marketing.
"In this capacity, she now covers all 16 of the Prince's charities and helps to proactively tell the story of these charities collectively and collaboratively."