The actress filed for divorce from Tom Cruise on June 29 after five years of marriage.
Holmes will begin production on Molly, a film she co-wrote. The movie centers on a single mother and her daughter.
Shooting is due to last to August in New York.
Cruise and Holmes are currently negotiating a divorce settlement and have no plans to take the case to court.
The 50-year-old is allegedly keen to keep the case out of the public eye.
Cruise reportedly exerted control over Holmes's career during their marriage.