The TV presenter has a genetic defect known as restricted hips and cartilage degeneration, and needs a hip operation that he has put off for ten years.
"I do have to have two hip replacements," he told The Sun.
"I will keep going until they fall off and then I will get them done.
"I'm aware of the pain every day - it's debilitating. If you dropped something on the floor now I couldn't bend down to pick it up."
He added: "I'm not going to get more flexibility as a result of the surgery but it might ease the pain."
Holmes explained that he has been "too chicken" to follow doctors' orders to have the operation to fix the defect, which leaves his bones rubbing together.
He also stated that he has become more aware of old age and death, and has chosen where he wants to rest after he dies.
"I know I want to be buried with my father in Belfast. If my father's plot is full with my other brothers or whatever then I want to be buried in the same cemetery as my mum.
"I think I want 'Now he can rest' or 'At least now he's having a sleep' because I think I have always been a man in a hurry."
The Sky News and ITV presenter topped a new UK TV rich list earlier this year, after reportedly earning £2.8 million.