The Anger Management star will be on hand to share his favourite memories from his long friendship with the legendary guitarist at the Hard Rock Café on Hollywood Boulevard.
Movie producer Robert Evans will also attend Slash's induction ceremony, as will hard rock singer Myles Kennedy.
Slash is to follow up the induction gala with a special acoustic performance for the fans in attendance.
The musician is one of many 2013 Hollywood Walk of Fame inductees. Usher, New Kids on the Block, the Backstreet Boys, Janis Joplin and Jane's Addiction are among the music acts who will be honoured.
Actors Javier Bardem, Helen Mirren, Simon Baker, Bryan Cranston and Glee's Jane Lynch will also give handprints to the famed Hollywood walkway.
Slash recently released his second solo album Apocalyptic Love.
Watch Slash's 'You're a Lie' music video below: