The actor said that he is fine with being labelled as handsome as he believes it has helped him in his career to date.
However, the Magic Mike star admitted that he knows he can't rely on his looks forever.
He told T2: "I just don't get it when I hear people say, 'I'm fighting my looks! I'm too pretty!' My parents are great looking people and I won the genetic lottery there.
"And, yes, you get more jobs because of those good genes. But your looks can't define you forever. Your acting will do it eventually."
Tatum previously worked as a stripper and a model - just like his character in the new film - and he said that he has had to work hard to improve his acting skills.
The 32-year-old said: "I never wanted to be an actor, and I had no artistic ambitions growing up. It all just fell into my lap.
"My looks got me into the industry, but it's taken me eight years to figure out the acting part."
Watch a Magic Mike video clip below: