Cruise and Holmes reached a divorce settlement on Monday (July 9), less then two weeks after they announced their separation in a joint statement.
Lopez revealed to Entertainment Tonight that she empathizes with Cruise and Holmes, especially since she went through her own public divorce from Marc Anthony last summer.
"I'm sad for them," Lopez said. "They're both really lovely people, and just like Marc and I, it's not what you want to happen. You fight and you try until you realise you can't anymore... I heard about [their divorce] when I was in South America and I was stunned."
Lopez added that her primary concern is the effect the divorce will have on Holmes and Cruise's daughter Suri.
"You know I just wish them, you know, peace in their decision. And really for Suri and their other children as well, because you become such a family," Lopez explained.
She continued: "It's not just Suri, it's Connor and Isabella and everybody, you know, you all become a family. And when that breaks apart, nobody wins, everybody's heartbroken in some way. And I just wish them peace."
Earlier this week, it was reported that Cruise may sue The National Enquirer over an article that accuses him of "abuse" and "humiliation".
Watch Tom Cruise in a Rock of Ages trailer below: