Sources are claiming that female film fans in particular are likely to avoid watching her movies in the future.
"Kristen's the most hated woman in Hollywood," a studio source told The Sun.
"Female moviegoers have been looking for a reason not to like her and now they have it.
"Lots of Rob's huge army of female fans will boycott her films. It's going to be a long road for her to come back, professionally as well as personally."
Robert Pattinson and Kristen Stewart will appear together in the final Twilight movie Breaking Dawn Part 2 later this year.
Pattinson has reportedly asked Stewart to move out of their shared home following the affair reports.
It has also been reported that Pattinson and Stewart are no longer on speaking terms following the scandal.