The reality-star-turned-presenter admitted that she'd hate to be under the same pressure as the likes of Kim Kardashian and Kate Moss, who are judged for their looks on a daily basis.
"Women are so unforgiving of themselves. We don't recognise our own beauty, because we're too busy comparing ourselves to other people," she told Glamour.
"No, we are not all Gisele Bundchen or Beyoncé but I can tell you even the most beautiful girls in the world have felt insecure.
"Just seeing the pressure my friends Kim Kardashian and Kate Moss are under makes me never want to be the prettiest in the room. There is no such thing as perfection.
"Try this - look in the mirror. Find one thing you like... think: 'Well, I've got this, and a lot of people don't'. You have to look at what you do have."
She added: "I call myself an FFP - former fat person. And when you're an FFP, you will always see in yourself what people used to bully you for."
Osbourne previously described her breasts as "empty sacks of s**t".